Monday, August 6, 2012

Phosphine-catalyzed asymmetric [4+1] annulation of Morita-Baylis-Hillman carbonates with dicyano-2-methylenebut-3-enoates

Phosphine-catalyzed asymmetric [4+1] annulation of Morita-Baylis-Hillman carbonates with dicyano-2-methylenebut-3-enoates:
Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2CC34619B, Communication
Xiao-nan Zhang, Hong-Ping Deng, Long Huang, Yin Wei, Min Shi
A novel asymmetric [4+1] cycloaddition of MBH carbonates with dicyano-2-methylenebut-3-enoates has been developed for the first time, providing an efficient and enantioselective synthesis of highly functionalized cyclopentenes bearing one all-carbon quaternary stereogenic center.
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