Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins

Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins:

Nature Chemistry 4, 900 (2012).
doi:10.1038/nchem.1454

Authors: Amanda J. Reig, Marcos M. Pires, Rae Ana Snyder, Yibing Wu, Hyunil Jo, Daniel W. Kulp, Susan E. Butch, Jennifer R. Calhoun, Thomas G. Szyperski, Edward I. Solomon & William F. DeGrado
Representing the first successful rational reprogramming of function in a de novo protein, the reactivity of a designed di-iron carboxylate protein from the Due Ferri family was altered from hydroquinone oxidation to arylamine N-hydroxylation through the introduction of a critical third histidine ligand in the active site.