Wednesday, March 21, 2012

The Stereochemical Course and Mechanism of the IspH Reaction

The Stereochemical Course and Mechanism of the IspH Reaction: Thumbnail image of graphical abstract
On the right path: The stereochemcial course of the IspH reaction, the last reaction in the deoxyxylulose phosphate pathway to terpenes, was investigated in feeding experiments with deuterated isotopologues of 1-deoxy-D-xylulose. The results support an enzyme mechanism for IspH that involves a previously suggested metallacyclopropane intermediate.

New function for Fe-S clusters

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