Synthesis and Stereoselective Interconversion of Chiral 1-Aza-3,6-diphosphacycloheptanes

Synthesis and Stereoselective Interconversion of Chiral 1-Aza-3,6-diphosphacycloheptanes:

1-Aza-3,6-diphosphacycloheptanes with chiral substituents on the nitrogen atoms were synthesized with the prevailing formation of meso stereoisomers (P_RP_S), which can form P,P-chelate platinum(II) complexes. In solution, the selective stereoconversion of the pure meso isomers into a mixture of P_RP_RC_S(R) and P_SP_SC_S(R) isomers was observed. Kinetic and DFT studies of this process were performed.

Interesting P2N ligands.